Evidence And Guidelines
Age Related Macular Degeneration
COLLEGE GUIDELINES
RCOphth ARMD Management September 2013
RCOphth ARMD Management Flow Chart September 2013
RCOphth Wet ARMD which anti vegF to use
RCOphth ARMD Maximising Capacity in AMD services July 2013
RCOphth commissioning ARMD Services – July 2007
NICE GUIDELINES
NICE guidelines Ranibizumab and Pegaptanib for the treatment of ARMD May 2012
NICE guidelines Alfibercept for wet ARMD July 2013
NICE guidelines PDT for wet ARMD September 2003
NICE Guidelines Ranibizumab for the treatment of CNV with pathological myopia November 2013
NICE TRANSPUPILLARY THERMOTHERAPY FOR ARMD May 2004
NICE Epiretinal brachytherapy for wet ARMD December 2011
NICE Limited Macular Translocation for ARMD May 2010
NICE Macular Translocation with 360 degrees retinotomy for wet ARMD May 2010
NICE Implantation of miniature lens system for advanced ARMD August 2008
NICE Radiotherapy for ARMD March 2004
NICE Epiretinal Brachytherapy for ARMD December 2011
LANDMARK TRIALS
1. Ranibizumab gives better outcomes for patients with wet ARMD. The MARINA trial compares ranibizumab to sham injection to show a statistical significant better outcome with Ranibizumab.
MARINA TRIAL Ranibizumab v sham 2006 for wet ARMD NEJM
ANCHOR TRAIL Ranibizumab v verteporfin v sham 2006 NEJM
2. MACUGEN (Pegaptanib) also gives better outcomes as demonstrated by the VISION trial
VISION Trial Macugen Pegaptanib for wet ARMD 2006 Ophthalmology
3. Aflibercept shows non inferiority to Ranibizumab in the treatment of wet ARMD
VIEW study 96 week results 2014
4. Age Related Eye Disease Study (AREDS) showed an approximately 25% reduced risk of ARMD in those at high risk. There was no benefit for those with no ARMD or early ARMD.
5. The Macular Photocoagulation Study
6. TAP study for photodynamic therapy
7. Bevacizumab shows equivalent results to Ranibizumab for the treatment of wet ARMD (Comparison of Age related macular degeneration Treatment Trial)
CATT trial Two year follow up ARMD
8. Ranibizumab for use in CNV associated with pathological myopia (RADIANCE Study)
RADIANCE Ranibizumab for CNV associated with pathological myopia March 2014 Ophthalmology
Sandwell & BMEC local Guidelines
Medical Retina Treatment Options And Pathway
Diabetic Retinopathy
RCOphth Diabetic Retinopathy Screening Preferred Practice 2010
RCOphth Diabetic Retinopathy Guidelines December 2012
RCOphth Iluvien for chronic DMO 2013
NICE guidelines ILUVIEN for chronic DMO November 2013
NICE guidelines Ranibizumab for the treatment of DMO April 2013
Diabetic Screening Service Revised Grading Definitions November 2012
Summary Diabetic Retinopathy Screening Grades
LANDMARK TRIALS
ETDRS Effect of aspirin treatment on DR
ETDRS Early Photocoagulation for DR
DRS Study Effect of PRP in reducing DR complications
FAME study A & B 3 year folow up Ophthalmology 2013
Retinal Vein Occlusion
RCOphth Retinal Vein Occlusion Management Guidelines December 2010
NICE Dexaethasone Intravitreal implant for CMO in RVO Jult 2011
NICE Arteriovenous crossing Sheathotomy for BRVO March 2010
NICE guidelines Ranibizumab for the treatment of macular oedema due to RVO May 2013
NICE guidelines Alfibercept for macular oedema secondary to CRVO February 2014
LANDMARK TRIALS
BVOS grid laser for MO and PRP for neovasuclarisation
CVOS M group study grid laser for MO
Patient Information Leaflets
RNIB Diabetes information leaflet
SWBH Annual diabetes eye screening April 2013
SWBH Fundus Fluorescein Angiography October 2014
SWBH Visudyne Therapy September 2014
RNIB Understanding Retinitis Pigmentosa leaflet
RCOphth Ocular Toxicity Of Hydroxychloroquine
NICE GUIDELINE
NICE Glaucoma diagnosis & management of COAG & OHT April 2009
GLAUCOMA Daignosis & Managment by National Collaborting Centre for Acute Car April 2009
NICE Glaucoma diagnosis & Management of COAG and OHT Quick Reference Guide April 2009
NICE TRABELUCAR STENT May 2011
NICE CANALOPLASTY FOR POAG May 2008
EGS GUIDELINE
EGS Terminology and Guidelines for Glaucoma 3rd Edition
Landmark Trials
Landmark-Glaucoma-Studies-Trial-Findings-Treatment-Lessons-PDF
Ocular Hypertension Treatment Study: Linking IOP and Onset of Glaucoma
OHTS Topical treatment delays or prevents POAG
OHTS Baseline factors that predict onset of POAG
Delaying Treatment of Ocular Hypertension
Collaborative Initial Glaucoma Treatment Study : Trabeculectomy v drugs for initial therapy
Collaborative Initial Glaucoma Treatment Study
Early Manifest Glaucoma Trial: Treat IOP early, follow progression closely
Collaborative Normal Tension Glaucoma Study : IOP reduction important even for normotensives
CNTG Study Effectiveness of IOP reduction in the treatment of NTG
Advanced Glaucoma Intervention Study: Effect of sequence in Surgical Procedures
AGIS Relationship between control of IOP and VF Deterioration
Tube v Trabeculectomy Study: Expanding the use of shunts
Three year Follow up of the Tuve v Trabeculectomy Study 2009
Fluorouracil filtering Surgery Study Ophthalmology 5 year follow up 1996
Glaucoma Laser Trial GLT comparing ALT with Medical therapy Ophthalmology 1990
Treatment Of Glaucoma In Pregnancy
Patient Leaflets
SWBH Closed Angle Glaucoma March 2014
SWBH Open Angle Glaucoma March 2014
NHS GLAUCOM A SERVICE – INFORMATION LEAFLET
Training
Herpetic Eye Disease Study
HEDS Oral Aciclovir for prevention of recurrent HSV eye disease
Keratoconus
NICE Corneal Collagen Cross Linking September 2013
Guidelines AE
SWBH Guidelines for the Management of Acanthamoeba Keratitis July 2013
SWBH Guidelines for the Management of Endogenous Endophthalmitis June 2014
SWBH Management of Herpes Zoster Ophthalmicus March 2012
SWBH Microbial Conjunctivitis; Ophthalmic Infections August 2012
SWBH Ophthalmia Neonatorum Guidelines
SWBH Ophthalmic Operational Guidelines; Intraocular Fluid Sampling 2009
SWBH Orbital Cellulitis and Abscess in Children (Ophth Paed 039) (SWBH)
SWBH Orbital Cellulitis and Orbital Abscess in Adults (Ophth038) (SWBH)
SWBH Papilloedema Guidelines for its management 2013
SWBH Post-operative Endophthalmitis Management Guidelines October 2014
SWBH Topical Ophthalmic Antibiotic Selection Guide (BMEC SWBH)
SWBH Topical Ophthalmic Antimicrobial Preparations Formulary (BMEC SWBH)
SWBH Topical Ophthalmic Antimicrobials in Pregnancy and Lactation
Cataract Guidelines
RCOphth Cataract Guidelines September 2010
Use of Prophylactic Antibiotic post phaco surgery (ESCRS study)
ESCRS Guidelines for use of prophylactic Antibiotics post cataract surgery
SWBH Cataracts and Cataract Surgery March 2014