Evidence And Guidelines

Age Related Macular Degeneration

COLLEGE GUIDELINEScollege of ophthalmologists

RCOphth ARMD Management September 2013

RCOphth ARMD Management Flow Chart September 2013

RCOphth Wet ARMD which anti vegF to use

RCOphth ARMD Maximising Capacity in AMD services July 2013

RCOphth commissioning ARMD Services – July 2007

 

 

NICE GUIDELINESNICE sign

NICE guidelines Ranibizumab and Pegaptanib for the treatment of ARMD May 2012

NICE guidelines Alfibercept for wet ARMD July 2013

NICE guidelines PDT for wet ARMD September 2003

NICE Guidelines Ranibizumab for the treatment of CNV with pathological myopia November 2013

 

NICE TRANSPUPILLARY THERMOTHERAPY FOR ARMD May 2004

NICE Epiretinal brachytherapy for wet ARMD December 2011

NICE Limited Macular Translocation for ARMD May 2010

NICE Macular Translocation with 360 degrees retinotomy for wet ARMD May 2010

NICE Implantation of miniature lens system for advanced ARMD August 2008

NICE Radiotherapy for ARMD March 2004

NICE Epiretinal Brachytherapy for ARMD December 2011

 

LANDMARK TRIALS

1. Ranibizumab gives better outcomes for patients with wet ARMD. The MARINA trial compares ranibizumab to sham injection to show a statistical significant better outcome with Ranibizumab.

MARINA TRIAL Ranibizumab v sham 2006 for wet ARMD NEJM

PIER study year 1 full text

PIER study year 2 full text

ANCHOR TRAIL Ranibizumab v verteporfin v sham 2006 NEJM

2. MACUGEN (Pegaptanib) also gives better outcomes as demonstrated by the VISION trial

VISION Trial Macugen Pegaptanib for wet ARMD 2006 Ophthalmology

3. Aflibercept shows non inferiority to Ranibizumab in the treatment of wet ARMD

VIEW study 96 week results 2014

4. Age Related Eye Disease Study (AREDS) showed an approximately 25% reduced risk of ARMD in those at high risk. There was no benefit for those with no ARMD or early ARMD.

AREDS ARMD Supplement 1

AREDS ARMD Supplement 2

5. The Macular Photocoagulation Study

 

6. TAP study for photodynamic therapy

 

7. Bevacizumab shows equivalent results to Ranibizumab for the treatment of wet ARMD (Comparison of Age related macular degeneration Treatment Trial)

CATT trial Two year follow up ARMD

8. Ranibizumab for use in CNV associated with pathological myopia (RADIANCE Study)

RADIANCE Ranibizumab for CNV associated with pathological myopia March 2014 Ophthalmology

 

 

Sandwell & BMEC local Guidelinessandwell anf wb logo

Medical Retina Treatment Options And Pathway

 

Diabetic Retinopathy

 

 

RCOphth Diabetic Retinopathy Screening Preferred Practice 2010college of ophthalmologists

RCOphth Diabetic Retinopathy Guidelines December 2012

RCOphth Iluvien for chronic DMO 2013

 

NICE guidelines ILUVIEN for chronic DMO November 2013

NICE guidelines Ranibizumab for the treatment of DMO April 2013NICE sign

 

Diabetic Screening Service Revised Grading Definitions November 2012DRSS logo

Summary Diabetic Retinopathy Screening Grades

LANDMARK TRIALS

ETDRS Effect of aspirin treatment on DR

ETDRS Early Photocoagulation for DR

DRS Study Effect of PRP in reducing DR complications

DCCT NEJM

FAME study A & B 3 year folow up Ophthalmology 2013

 

 

Retinal Vein Occlusion

 

college of ophthalmologists

RCOphth Retinal Vein Occlusion Management Guidelines December 2010

NICE Dexaethasone Intravitreal implant for CMO in RVO Jult 2011

NICE Arteriovenous crossing Sheathotomy for BRVO March 2010NICE sign

NICE guidelines Ranibizumab for the treatment of macular oedema due to RVO May 2013

NICE guidelines Alfibercept for macular oedema secondary to CRVO February 2014

 

LANDMARK TRIALS

BVOS grid laser for MO and PRP for neovasuclarisation

CVOS M group study grid laser for MO

 

Patient Information Leaflets

 

Avastin

Ranibizumab For ARMD

RNIB Diabetes information leaflet

SWBH Annual diabetes eye screening April 2013

SWBH Fundus Fluorescein Angiography October 2014

SWBH Visudyne Therapy September 2014

RNIB Understanding Retinitis Pigmentosa leaflet

 

TIA Referrals

RCOphth Ocular Toxicity Of Hydroxychloroquine

 

 

NICE GUIDELINENICE sign

NICE Glaucoma diagnosis & management of COAG & OHT April 2009

GLAUCOMA Daignosis & Managment by National Collaborting Centre for Acute Car April 2009

NICE Glaucoma diagnosis & Management of COAG and OHT Quick Reference Guide April 2009

NICE TRABELUCAR STENT May 2011

NICE TRABECULOTOMY May 2011

NICE CANALOPLASTY FOR POAG May 2008

 

EGS GUIDELINEEGS logo

EGS Terminology and Guidelines for Glaucoma 3rd Edition

 

Landmark Trials

 Landmark-Glaucoma-Studies-Trial-Findings-Treatment-Lessons-PDF

Ocular Hypertension Treatment Study: Linking IOP and Onset of Glaucoma

OHTS Topical treatment delays or prevents POAG

OHTS Baseline factors that predict onset of POAG

Delaying Treatment of Ocular Hypertension

Collaborative Initial Glaucoma Treatment Study : Trabeculectomy v drugs for initial therapy

Collaborative Initial Glaucoma Treatment Study

Early Manifest Glaucoma Trial: Treat IOP early, follow progression closely

Early Manifest Glaucoma Trial

Collaborative Normal Tension Glaucoma Study : IOP reduction important even for normotensives

CNTG Study Effectiveness of IOP reduction in the treatment of NTG

Advanced Glaucoma Intervention Study: Effect of sequence in Surgical Procedures

AGIS Relationship between control of IOP and VF Deterioration

Tube v Trabeculectomy Study: Expanding the use of shuntsThree year followup of tube v trab abstractAqueous shunts in glaucoma

Aqueous Shunts in Glaucoma

Three year Follow up of the Tuve v Trabeculectomy Study 2009

Fluorouracil filtering Surgery Study Ophthalmology 5 year follow up 1996

Glaucoma Laser Trial GLT comparing ALT with Medical therapy Ophthalmology 1990

 

Tipping Point

Treatment Of Glaucoma In Pregnancy

Side Effects of Topiramate

Side Effects Of Vigabatrin

 

Patient Leaflets

SWBH Closed Angle Glaucoma March 2014

SWBH Open Angle Glaucoma March 2014

Congenital Glaucoma

ISTENT

Glaucoma RNIB Booklet

NHS GLAUCOM A SERVICE – INFORMATION LEAFLET

 

Training

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